While brief episodes of “feeling depressed” are part of the human experience, prolonged, severe, or clinical depression can make it very difficult or even impossible to get out of bed in the morning and function normally.
Rated 2.6 / 5 (How Ratings Work)
Possible to probable range of efficacy of cannabis for treatment of depression.
Based on 27 Studies from 1995 - 2018
Study Name, Description & Year
Rating
CB1 Cannabinoid Receptor Ligands Augment The Antidepressant-like Activity Of Biometals (magnesium And Zinc) In The Behavioural Tests.
Animal study (mice) — 2018
Cannabinoids Prevent Depressive-like Symptoms And Alterations In BDNF Expression In A Rat Model Of PTSD
Animal study (rats) — 2018
Endocannabinoid Signalling Modulates Susceptibility To Traumatic Stress Exposure
Animal study (mice) — 2017
Cannabis As A Substitute For Prescription Drugs - A Cross-sectional Study
A survey conducted on 1248 cannabis-using patients who were recruited through social media and cannabis dispensaries in Washington State. — 2017
Plastic And Neuroprotective Mechanisms Involved In The Therapeutic Effects Of Cannabidiol In Psychiatric Disorders
Review — 2017
Antidepressant-like Effect Of Cannabidiol Injection Into The Ventral Medial Prefrontal Cortex-Possible Involvement Of 5-HT1A And CB1 Receptors
Animals study (rats) — 2016
Cannabidiol Induces Rapid-acting Antidepressant-like Effects And Enhances Cortical 5-HT/glutamate Neurotransmission: Role Of 5-HT1A Receptors
Animal (mice) — 2016
Crosstalk Between Endocannabinoid And Immune Systems: A Potential Dysregulation In Depression?
Review — 2016
Prohedonic Effect Of Cannabidiol In A Rat Model Of Depression
Animal study (Wistar rats) — 2016
Splendor In The Grass? A Pilot Study Assessing The Impact Of Medical Marijuana On Executive Function
A survey of 11 medical cannabis patients — 2016
β-Caryophyllene, A CB2 Receptor Agonist Produces Multiple Behavioral Changes Relevant To Anxiety And Depression In Mice
Animal study (mice) — 2014
Effect Of Delta-9-tetrahydrocannabinol On Behavioral Despair And On Pre- And Postsynaptic Serotonergic Transmission
Animal study (rats) — 2012
Multiple Mechanisms Involved In The Large-spectrum Therapeutic Potential Of Cannabidiol In Psychiatric Disorders
Review — 2012
Cannabidiol As An Emergent Therapeutic Strategy For Lessening The Impact Of Inflammation On Oxidative Stress
Review — 2011
Antidepressant-like Effect Of Δ9-tetrahydrocannabinol And Other Cannabinoids Isolated From Cannabis Sativa L
Animal study (mice) — 2010
Uso Terapêutico Dos Canabinoides Em Psiquiatria [Therapeutical Use Of The Cannabinoids In Psychiatry]
Meta-analysis — 2010
Marijuana Effectiveness As An HIV Self-care Strategy
775 humans living with HIV/AIDS — 2009
5-HT1A Receptors Are Involved In The Cannabidiol-induced Attenuation Of Behavioural And Cardiovascular Responses To Acute Restraint Stress In Rats
Animal study (Wistar rats) — 2009
Regulation Of Endocannabinoid Signaling By Stress: Implications For Stress-related Affective Disorders.
Review — 2008
Cannabinoids Elicit Antidepressant-like Behavior And Activate Serotonergic Neurons Through The Medial Prefrontal Cortex
Animal study (rats) — 2007
Local Enhancement Of Cannabinoid CB1 Receptor Signalling In The Dorsal Hippocampus Elicits An Antidepressant-like Effect
Animal study (rats) — 2007
Cannabinoids Promote Embryonic And Adult Hippocampus Neurogenesis And Produce Anxiolytic- And Antidepressant-like Effects
Animal and laboratory study (rats) — 2007
Survey Of Australians Using Cannabis For Medical Purposes
Survey conducted on 128 cannabis-using patients. — 2005
Preliminary Observation With Dronabinol In Patients With Intractable Pruritus Secondary To Cholestatic Liver Disease
Human clinical study (3 patients) — 2002
Dronabinol As A Treatment For Anorexia Associated With Weight Loss In Patients With AIDS
139 patients living with AIDS — 1995